This work aimed to improve carvedilol dissolution through preparation of nanoparticles to be formulated as buccoadhesive gel. Drug excipients compatibility was studied using fourier transform infra-red spectroscopy and differential scanning calorimetry. Carvedilol nanoparticles were prepared by nanoprecipitation method using Eudragit® RS100 as a polymer and poloxamer 407 as a stabilizer. Eight nanoparticles formulations were prepared adopting a 41×21 factorial design. The nanoparticles appearance was spherical and uniform. The particle size of the prepared formulations ranged from 149 to 177 nm and it wasn’t significantly affected by any of the tested formulation variables. On the other hand, changing the drug to polymer ratio significantly affected both drug loading and dissolution parameters (P value < 0.05). Drug loading ranged from 76.2-95.97%. The release data showed fickian diffusion mechanism. The formula of choice was suspended in 4% w/v HPMC gel. The gel had pH of 6.36, pseudoplastic flow and acceptable bioadhesion which are required for buccal application. It enhanced drug permeation through chicken pouch membrane in comparison to control drug gel of the same concentration and it was physically and chemically stable on storage for six months at 40±2°C /75±5%RH and one year at 5±3°C.
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